TroVax Studied For The Treatment Of Malignant Mesothelioma

Mesothelioma NewsTroVax studied in the treatment of mesothelioma

New York, NY - May 19, 2011

Oxford Biomedica has awarded New York-based pharmaceutical giant Pfizer non-exclusive rights to the diagnostic use of antibodies directed against the tumor antigen 5T4 and an option to sell a diagnosis based on 5T4. BioMedica and Wyeth entered into a therapeutic approach in 2001 was acquired by Pfizer in 2009. This agreement grants rights to Wyeth antibodies directed to the global market for all cancer indications 5T4.

The 5T4 antigen is the objective of Phase II BioMedica therapeutic measures against TroVax cancer vaccine, which is based on a modified vaccinia virus Ankara (MVA), which provides the 5T4 antigen. BioMedica study is to evaluate the effectiveness of TroVax in combination with docetaxel in the treatment of hormone-refractory prostate cancer (HRPC).

In addition, phase I / II study evaluated TroVax treatment with first line chemotherapy for mesothelioma is scheduled to begin in 2011, as the study of patients with ovarian cancer. Malignant mesothelioma is a rare tumor protective lining of the lungs, heart, chest and abdomen, which is almost entirely due to the long-term exposure to asbestos.

Combination therapy of mesothelioma surgery, chemotherapy and radiation, but is not healing. Mesothelioma takes on average 40 years to develop and is asymptomatic until it reaches its later stages, so it is very difficult to diagnose. Mesothelioma is most common, life expectancy is expected to be approximately six months after detection.

Although the phase III study evaluating Trist TroVax in metastatic renal cell carcinoma failed primary endpoint, the results of tests found TroVax subgroups of patients who can be of significant benefit. This led to the development of an algorithm, called the immune response against a substitute (IRS), which "gives us the opportunity to address more effectively respond to the group of patients, and we are sure that this is a novel biomarker to further substantiate the results of the current phase of development TroVax II clinical development, "said Stuart Naylor, Biomedical CSO.

Function Mesothelioma Buffalo Police Officer May Make Other City Employees Affected By

Buffalo police have mesothelioma costume can lead to other workers interested in coming to town

William J. Rieman, a former Buffalo, New York cop who suffers from the latter stages of mesothelioma, a rare cancer of the protective membrane of the principal body cavities and organs, will be awarded a $ 1.7 million, which solves a further $ 7,000,000 U.S. dollar has filed against the city. It has been argued that the malignant mesothelioma Rieman, which was caused almost exclusively by exposure to asbestos developed because it is inhaled, is carcinogenic mineral fibers, while working in various buildings belonging to the city.

"State of New York had already assigned agent Rieman disability claims based on the likelihood of her cancer may have been caused by his work environment. Since we have agreed with our lawyers that the solution was the best option in this case, explained Council Assertions Committee Chairman David Rivera. "This is not an easy thing to do for just $ 1.7 million. You really compelling reasons ... it is the taxpayers' money, and we want to make sure we are fiscally responsible. "

Rieman, 44, worked for the city for 20 years and in the city-owned buildings which were found to contain asbestos. He was diagnosed with the disease of mesothelioma in 2008, lasting 20 to 50 years to develop, is likely to Rieman been exposed to asbestos during his career. And if Reiman was affected, it is possible that other cities, workers may develop cancer from asbestos.

"Certainly we are concerned," said Rivera. "Right now we do not know other reports of adverse reactions like this, but you never know."

Former Fullback For The Buffalo Bills In Charge Of Handling Illegal Asbestos

Buffalo, New York City firefighter and former Buffalo Bills back Dr. Sean P., 44, was criminally charged with illegally handling asbestos. Asbestos is a mineral very toxic, which was used in the industries of construction and manufacturing in the 19th and 20th century. use of asbestos was banned in the United States in 1989 for causing a wide range of deadly diseases like lung cancer asbestosis and mesothelioma, a rare cancer of the protective membrane of the lungs, the stomach and the chest wall.

Medical owns and operates an asbestos removal company in Grand Island, NY called SD Specialty Services. Violations of federal law to clean air has been found at the Environmental Protection Agency (EPA) and the State Department of Environmental Conservation (DEC) conducted a raid authorized by the court on the property. The investigation revealed a "significant amount" of asbestos-containing material was not properly secured, marked or deposited.

Asbestos handled incorrectly can cause microscopic cancer of fibers in the air, which increases the probability that people nearby to inhale them. Once in the body, the asbestos fibers are deposited in tissues for decades, for decades, and may eventually lead to the onset of the disease mesothelioma. This aggressive type of cancer is a silent killer, which is usually detected too late to save patients 'lives'.

"Through the study, it was decided that the asbestos-containing material on the Site entered projects [Dr.] was working," said attorney Aaron J. Mango.

Test For Successful Protein Diagnostic Pleural Mesothelioma In Early Stages

Researchers at the University of New York Langon NYU Medical Center and Cancer Institute in New York has resulted in trials at the National Cancer Institute Early Detection Research Network Biomarker Discovery Lab with what they now call the biomarker most accurate in detecting proteins secreted by tumors asbestos cancer. The test results were SomaLogic aptamer Inc. proteomics platform presented at AACR 102: Annual Meeting 2011, e between April 2 and 6 site.

Scientists have found that the proteomic analysis detected 15 of 19 cases of malignant pleural mesothelioma who were in phase 1 or phase 2. Mesothelioma is a rare cancer that affects the protective lining of major organs and body cavities and is caused almost exclusively by exposure to asbestos. The pleural mesothelioma is specific to the lining of the lungs, which means that the platform specifically detects lung mesothelioma, but not necessarily the heart, chest or abdomen.

The test was considered 100% specific, meaning that there was one false positive in this study and its sensitivity was assessed at 80% to detect the presence of an early cancer. Mesothelioma is usually very difficult to detect and is usually diagnosed only when it becomes symptomatic around the scene three or four, which makes it difficult to treat and almost impossible to beat.

"Only patients who seem to benefit from treatment of mesothelioma are those who are in Stage 1 and this is only 10-15 percent of patients," said the head of the Division of Thoracic Surgery and Thoracic Oncology at the Langone NYU Medical Center, Harvey I. Pass, MD, who believes that a diagnostic tool could be a turning circuit breaker.

School Students Basic Exposure To Asbestos During The Classroom Experience

Approximately 70 students have been exposed to asbestos in a school in West Berkshire, England, after the explosion damaged a ceiling a science classroom. Students and a small number of employees were evacuated from the primary school Kintbury St Mary's reaction after a sound lifted the ceiling tiles, releasing small amounts of asbestos dust. Health workers and security forces cordoned off the school uniforms and sent for analysis.

Asbestos is highly toxic mineral wool factories that are often in old school buildings, since two of the last century has been used in the manufacture of various materials such as tiles, paints, coatings and insulation. The use of asbestos is now banned in most nations of the world's first, but is still present in large structures, where the interference is a serious health risk. Scraping, breakage or cracking of materials containing asbestos, lead, microscopic asbestos fibers can cause asbestosis, lung cancer or mesothelioma, a rare cancer of the protective coating of the main body cavities and organs.

"It is well known that the insulation panels in the ceiling, which contained low levels of asbestos," said Phil Spray, spokesman for the local education authority. "Agents of health and safety of the LEA attended school and completed tests in the room. They tested positive for asbestos dust, although the level was very low. "

It has been a longstanding debate about how much asbestos is required to induce the development of deadly diseases such as malignant mesothelioma. Some experts say that a single exposure is sufficient, while others believe prolonged exposure is necessary.

Relatives Of British Victims Of Mesothelioma Are Trying To Tata Steel

The multinational Tata Steel Company has been brought six-figure sum to the Williams family, Jim, died of cancer mesothelioma in 2008. This is an aggressive and incurable cancer caused almost exclusively by long-term exposure to asbestos and it affects the protective lining of the major organs and body cavities.

According to an application by lawyers for the family, Williams has been exposed to asbestos between 1963 and 1967 while working in the department of labor in the former steel mills of John Lysaght. The exhibition is supposed to have been concentrated around the pits in the works he regularly went down to sweep the dust and dirt. The debris may contain asbestos, which was probably released from pipes near or soaking pits, both of whom had asbestos lagging.

Williams, a native of Scunthorpe, England, died at the age of 71 years, three months after being diagnosed with pleural mesothelioma, which affects the lining of the lungs. To diagnosis, was the picture of health. Asbestos victims rarely realize they have been exposed to asbestos, mesothelioma and it takes an average of 40 years to develop and is not usually the symptoms until the patient reaches stage three or four are rarely diagnosed in time for mesothelioma treatment dramatically improve the prognosis.

Work Lysaght, who employed Williams, and was renamed Normanby Park, closed 30 years ago. A representative of Tata was willing to say: "We are aware of the case and it is viewed by our legal representatives."